Associate Director, Head of Histology - Rare Diseases Drug Discovery

Company: Takeda Pharmaceutical
Location: Quincy
Posted on: May 9, 2022

Job Description:

By clicking the "Apply" button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda's and . I further attest that all information I submit in my employment application is true to the best of my knowledge.Job DescriptionOBJECTIVES We are looking for someone who will share our excitement about science, contribute to our inclusive culture, and honor our commitment to patients.As the Head of Histology, you will join the growing Translational Sciences team within the Rare Diseases Drug Discovery Unit (RD DDU), reporting to the Head of Translational Sciences Rare Diseases DDU. You will lead a team of dedicated scientists responsible for delivery of histopharmacological and histopathology data to support drug discovery in rare metabolic and hematologic diseases. You will be an essential member of the RD DDU leadership team and will manage the histology laboratory, biomarker development, mechanistic investigations, and digital imaging applications. This exciting role is suited for someone with successful management experience and outstanding hands-on skills in all aspects of routine histology and in developing multiplexing IF, IHC, and ISH biomarker assays, microscopy, image analysis, data interpretation, and study report preparation. You will also oversee the design and implementation of PK/PD/efficacy assessments to support project advancement, participate in interdisciplinary project teams, and lead collaborations.ACCOUNTABILITIES

• Provide scientific and technical leadership to a team of 5 scientists and histology technologists to ensure delivery of high-quality data
• Be a primary point of contact for all aspects of histology needs of the RD DDU to support advancement of projects from discovery to early development
• Maintain and optimize the interface of the histopharmacology team with the project teams to create timelines to meet project deadlines
• Develop strategies for the assessment and interpretation of morphologic changes and PK/PD/efficacy biomarker data from animal studies to determine the mechanism of action (MoA) and establish proof of concept (PoC) to support drug discovery and early development.
• Guide development of novel PK/PD/efficacy biomarkers and histopathologic methods
• Perform integrative gross and microscopic primary reads, interpret observations, and determine the significance of histopharmacology data from MoA and PoC studies in animal models of disease
• Author and review study reports and regulatory documents
• Communicate interpretation and effect of histopharmacology data to a broad audience in study reports, regulatory documents, and project team meetings
• Work in an environment spanning discovery and development and work with a variety of stakeholders, including Discovery Biology, Global Gene Therapy, Drug Safety, DMPK and others
• Maintain a high level of scientific expertise through literature reviews, congresses and seminar attendances, and networking with essential opinion leader
• Lead efforts to integrate the histopharmacology team in the organization-wide platforms, such as sample biorepositories, data management systems, and image analysis platforms
• Initiate and maintain collaborative interactions with other translational and histology teams across the organizationEDUCATION, COMPETENCIES AND SKILLS:
  • PhD or an equivalent degree in histology or related disciplines with 7+ years of experience in a relevant industry or academic role in histology research (or MS with 13+ years of experience, BS with 15+ years of experience)
  • 5 years of industry experience
  • 5 years of managerial experience
  • Expertise in histology, light/fluorescence microscopy, confocal microscopy, and image analysis is required
  • Experience in critically evaluating disease relevant animal models and translatable biomarkers to support drug discovery
  • Expertise in gene and cell therapy for rare lysosomal storage disorders and other inborn errors of metabolism is a plusColorado applicants are excluded from this posting.Employees are eligible to participate in Medical, Dental. Vision, Life Insurance, 401(k), Charitable Contribution Match, Company Holidays, Personal & Vacation Days, Student Loan Repayment Program and Paid Volunteer Time Off.Effective November 1, 2021, absent an approved religious or medical reason, all US office-based and lab-based Takeda employees who work fully on-site or in a hybrid model (as determined by Takeda) must be fully vaccinated to work at a Takeda site or to engage with Takeda colleagues or anyone else on behalf of Takeda. As of the same date, absent an approved religious or medical reason, US field-based employees, employees must be fully vaccinated in order to continue in their current roles. US employees who work at a Takeda manufacturing facility, and those who work at a BioLife center or BioLife lab, may be subject to different guidelines. Candidates are encouraged to speak with their recruiter to seek further information on the applicable guidelines for the Business Unit/Function for which they have applied.EEO StatementTakeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.LocationsUSA - MA - Cambridge - Binney StWorker TypeEmployeeWorker Sub-TypeRegularTime TypeFull time

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