Senior Research Associate II, Global Biologics Assay Team

Company: Takeda Pharmaceutical
Location: Quincy
Posted on: May 9, 2022

Job Description:

By clicking the "Apply" button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda's and . I further attest that all information I submit in my employment application is true to the best of my knowledge.Job DescriptionAbout the role:At Takeda, we are a forward-looking, world-class R&D organization that unlocks innovation and delivers transformative therapies to patients. By focusing R&D efforts on four therapeutic areas and other targeted investments, we push the boundaries of what is possible in order to bring life-changing therapies to patients worldwide.Join Takeda as a Senior Research Associate II where you will perform complex cell based assay assignments independently in the field of cell therapies for cancer drug discovery. You will also contribute to experimental design and complex problem resolution within project scope, and have relative experience on CAR production and functional evaluation in vitro. As part of the Therapeutic Generation and Screening team, you will report to the Senior Scientist and work with the Global Biologics organization.How you will contribute:

• Develop and implement bioanalytical strategies to support drug programs (e.g. IO/GI/CNS/Rare disease) to enable lead selection.
• Assist in experiment design, implement and troubleshoot experiments and execute data analysis of high throughput cell based assays to access biologics (e.g., mAb, T cell engagers) and cell therapy new modalities (e.g., CAR-T, CAR-NK).
• Collaborate with automation engineers to identify suitable approaches to utilize laboratory automation for the execution of variable cell based assays.
• CAR T/NK generation (stimulation, transduction and expansion) and functional evaluation of CAR expression, phenotyping, cytokine detection and killing potency in vitro.
• Use assigned literature to increase knowledge base and implement improvements.
• Develop clear protocols and maintaining a timely and accurate electronic lab notebook.
• Communicate research and development findings with internal and external partners.Minimum Requirements/Qualifications:
  • MS in a cell immunology, protein/antibody science, molecular biology, bioinformatics and/or equivalent relevant work experience with 2+ years experience.
  • BS in a cell immunology, protein/antibody science, molecular biology, bioinformatics and/or equivalent relevant work experience with 4+ years experience.
  • Master degree in cell immunology, protein/antibody science, molecular biology, bioinformatics and/or > 2 years equivalent relevant work experience with strong knowledge of T/NK cell biology, immuno-oncology, and cell therapy. Bachelor's degree with > 6 years relevant experience.
  • Tissue culture including application of aseptic techniques for media compounding, passaging, maintenance and cryopreservation of cell cultures.
  • Experience with immune cell (T/NK cells) isolation, culture and engineering.
  • Proficiency in immune cell phenotyping (surface/intracellular), cytokine detection (multi-color flow cytometry, Luminex), cytotoxicity assay and other immune related assays.
  • Proficient in data generation (prism, excel), presentation and troubleshooting.
  • Basic molecular biology skills are required, advanced skills highly desired.
  • Experience with viral delivery methods is a plus.
  • Experience performing and interpreting transcriptomics with bulk RNAseq and scRNAseq systems to interrogate biological mechanisms in cell lines is a plus.
  • Strong organizational and record keeping skills.
  • Capable to work independently to solve scientific questions.
  • Dedication to working in a team-oriented environment to contribute to shared projects.
  • Develop and oversee novel scientific projects and will manage the work of others directly or in a matrixed structure.What Takeda can offer you:
    • Comprehensive Healthcare: Medical, Dental, and Vision
    • Financial Planning & Stability: 401(k) with company match and Annual Retirement Contribution Plan
    • Health & Wellness programs including onsite flu shots and health screenings
    • Generous time off for vacation and the option to purchase additional vacation days
    • Community Outreach Programs and company match of charitable contributions
    • Family Planning Support
    • Flexible Work Paths
    • Tuition reimbursementMore about us:At Takeda, we are transforming patient care through the development of novel specialty pharmaceuticals and best in class patient support programs. Takeda is a patient-focused company that will inspire and empower you to grow through life-changing work.Certified as a Global Top Employer, Takeda offers stimulating careers, encourages innovation, and strives for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.Takeda U.S. Vaccine Requirement:Absent an approved religious or medical reason, all US office-based and lab-based Takeda employees who work fully on-site or in a hybrid model (as determined by Takeda) must be fully vaccinated to work at a Takeda site or to engage with Takeda colleagues or anyone else on behalf of Takeda. US field-based employees must be fully vaccinated as a condition of employment, absent an approved religious or medical reason. US employees who work at a Takeda manufacturing facility, and those who work at a BioLife center or BioLife lab, may be subject to different guidelines. If you are contacted by a Takeda recruiter about your job application, we encourage you to seek more information on the applicable guidelines for the Business Unit/Function to which you have applied.In accordance with the CO Equal Pay Act, Colorado Applicants Are Not Permitted to Apply.#LI-SGMEEO StatementTakeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.LocationsBoston, MAWorker TypeEmployeeWorker Sub-TypeRegularTime TypeFull time

Keywords: Takeda Pharmaceutical, Quincy , Senior Research Associate II, Global Biologics Assay Team, Other , Quincy, Massachusetts