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Scientist, Upstream Antibody Discovery

Company: Twist Bioscience
Location: Quincy
Posted on: November 25, 2022

Job Description:

Abveris (now a part of Twist Bioscience) is Boston's premier antibody discovery company providing contract research services to the biopharma industry. Abveris applies advanced immunization methods combined with B cell screening and hybridoma-based antibody discovery technologies to provide comprehensive reagent and therapeutic antibody discovery services. Abveris is developing the next generation of biologics, cell therapies, vaccines, and diagnostics in partnership with global leaders in biopharma.
We are seeking an experienced and motivated individual to join our team and expand our antibody discovery capabilities. Using state-of-the-art technology coupled with intelligent project and assay design, the candidate would accelerate our upstream process and guide selection of ideal single B cells, hybridoma clones and stable cell lines. Highly qualified candidates will be able to combine exemplary benchwork with the ability to analyze complex data sets and translate them into actionable, intelligible data reports.
Primary Responsibilities

  • Cell culture, including hybridoma and other cell line maintenance, scale-up and antibody production
  • Application of microfluidics-based selections of antigen-specific B cells using the Berkeley Lights Beacon
  • Detailed reagent preparation and validation
  • Mammalian cell transfections and stable cell line generation
  • Process efficiency and automation implementation
  • Responsible for preparing and clearly presenting data in a variety of cross-functional meetings under specific timelines
  • Effectively communicate and coordinate work within a highly matrixed workflow and collaborative environment
    • PhD in biological sciences with 0-2 years of experience, or MS in biological sciences with at least 4 years of experience in a laboratory setting
    • Prior laboratory experience in a biologics industry setting required
    • Ideal candidates will have direct experience in single B-cell (i.e. B cell cloning) and/or hybridoma -based antibody discovery workflows
    • Prior experience establishing and validating antibody-based functional assays, antibody characterization processes, and/or automating biology workflows
    • Keen understanding of the antibody discovery process
    • Exceptional verbal and written communication skills
    • Detail oriented with proven ability to troubleshoot complex problems with diverse variables
    • Ability to critically and independently evaluate data

Keywords: Twist Bioscience, Quincy , Scientist, Upstream Antibody Discovery, Other , Quincy, Massachusetts

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